| Autor: |
Cathie Garnis, Mike Gorenchtein, Yuqi Zhu, Rebecca Towle, Christopher Td Dickman, Catherine F. Poh |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
JBR Journal of Interdisciplinary Medicine and Dental Science. |
| ISSN: |
2376-032X |
| DOI: |
10.4172/2376-032x.1000131 |
| Popis: |
Introduction: The main etiological factor for oral squamous cell carcinoma (OSCC) is tobacco use; however nonsmoking cases have also been reported. The molecular basis of emerging oral malignancy in non-smokers is poorly understood. We seek to profile the microRNA patterns in this subset of patients. Methods: We evaluated global microRNA expression in multiple biopsies representing varied stages of oral cancer/pre-cancer taken from a single, contiguous field of diseased oral tissue. Results: We find distinct lists of frequently deregulated microRNA in each field. MiR-155 was selected for further validation in an independent cohort comprised of tissues from smokers and non-smokers. Highly expressed miR-155 was identified in 58% of OSCC cases and 83% of dysplasia cases. Conclusions: We conclude that miR-155 may be a driver of oral tumorigenesis and that molecular heterogeneity across fields of diseased tissue has significant implications when selecting candidates for development of targeted therapies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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