| Popis: |
Although success rates of microsurgical transfer steadily have increased during the last decade, microvascular thrombosis remains a major concern as a cause of flap failure. Nevertheless, at present no evidence-based guidelines on pharmacological prevention of microvascular thrombosis exist. In an attempt to reduce the risk of microvascular thrombosis, microsurgeons often apply antithrombotic protocols with different agents, dosages, and timing, often based solely on anecdotal evidence or personal experience. The authors review the most important pharmacological agents used for anticoagulation in microsurgical free flap transfer. A summary of current data is provided to assist the physician in designing a rational approach to anticoagulation in microsurgery. |
