| Autor: |
P. J. A. Capel, P. Faaber, Jo H. M. Berden, G. P. M. Rijke, L. B. A. Van De Putte, Ruud J.T. Smeenk |
| Rok vydání: |
1985 |
| Předmět: |
|
| DOI: |
10.1016/b978-0-08-033215-4.50075-3 |
| Popis: |
Publisher Summary Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of a great variety of apparently unrelated antibodies, thought to be a consequence of polyclonal B cell activation. The recognition of molecules with repeating negatively charged groups by anti-DNA antibodies was further substantiated by the finding that the anionic sulfonated polyaromatic dye Cibacron blue F3GA coupled to Sepharose C14B (CB) could be used to purify anti-DNA antibodies from SLE sera. At this moment, a large number of cross-reactive antigens are recognized by monoclonal and polyclonal anti-DNA antibodies. Based on the cross-reactions with phospholipids it has been suggested that phosphodiester linked phosphate groups are the cross-reactive moieties. It is possible that a number of auto-antibody specificities apparently present in SLE sera are caused by anti-DNA antibodies. These cross-reactions might also have implications for the immunopathological events that are operative in SLE. Most tissue lesions in SLE are considered to be the consequence of depositions of DNA anti-DNA immune complexes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
