Potent and selective inhibitors of gelatinase-A 2. carboxylic and phosphonic acid derivatives

Autor:	Byron A. Boyce, Nigel Robert Arnold Beeley, J. Richard Morphy, Andrew T. Millican, Joanna Leonard, Barbara Mason, Kenneth Millar, John Robert Porter, O'connell James Philip
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Zinc binding Stereochemistry Carboxylic acid Organic Chemistry Clinical Biochemistry Gelatinase A Pharmaceutical Science Biochemistry Phosphonic acid derivatives chemistry Drug Discovery Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 4:2747-2752
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)80588-6
Popis:	A series of zinc binding groups was introduced into a pseudopeptide sequence containing aromatic groups in the P1′ position in order to obtain selective inhibitors of gelatinase-A. Carboxylic acid and phosphonic acid groups provided the most potent inhibitors
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7cb5c9f340d96dd6d0ec92d0ab252ea4 https://doi.org/10.1016/s0960-894x(01)80588-6 Zobrazit plný text záznamu