Tumor Necrosis Factor alpha 238 G/A polymorphism and its relation to severity and cardiovascular risk in psoriasis

Autor:	Khaled Ahmed Mohamed Ali, Sahar El Sayed Ahmed, N N ElKhazragy, M.H. El-Sayed, M S Attia
Rok vydání:	2020
Předmět:	medicine.medical_specialty business.industry Internal medicine Psoriasis medicine Tumor necrosis factor alpha General Medicine medicine.disease business Gastroenterology
Zdroj:	QJM: An International Journal of Medicine. 113
ISSN:	1460-2393 1460-2725
Popis:	Background Psoriasis is known as chronic immune-mediated inflammatory skin disease affecting about 3% of the world’s population. Cytokine gene polymorphism attracted considerable interest as they have been found to alter gene transcription thereby influencing inflammatory processes in response to various diseases. Subjects A total of 50 psoraitic patients and 50 controls were genotyped for TNF–α −238G/A polymorphism by using polymerase chain reaction. ECG and lipid profile were done to assess cardiovascular risk. Results Polymorphism of TNF–α −238 was not found to be associated with an increased risk for psoriasis (p value 0.98). There is significant difference between cases and controls as regard systolic and diastolic blood pressure . Conclusion Our findings suggest that there is no association between TNF alpha polymorphism and risk of psoriasis in Egyptian psoraitic patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7cac4974687cc4604e5a5e33e7b4ec7e https://doi.org/10.1093/qjmed/hcaa046.002 Zobrazit plný text záznamu