The synthesis of 5′-[14C1] and 3a, 4-[13C2] labelled panadiplon (U-78875; 3-(5′-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)-imidazo-[1,5a]-quinoxalin-4(5H)-one)
| Autor: | M. R. Howard, L. G. Dring, M. J. Ackland |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Carboxylic acid Organic Chemistry Panadiplon Nuclear magnetic resonance spectroscopy Biochemistry Analytical Chemistry Cyclopropane chemistry.chemical_compound chemistry Drug Discovery Lactam medicine Radiology Nuclear Medicine and imaging Spectroscopy medicine.drug |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 33:517-525 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580330609 |
| Popis: | 5′-[14C1]Panadiplon was prepared in 3 steps starting from [14C1]cyclopropane carboxylic acid and 3-(5′-cyano-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)-imidazo-[1,5a]-quinoxalin-4(5H)-one. 3a, 4-[13C2]Panadiplon was prepared in two steps from 13C2-oxalic acid and N-1-(1-methylethyl)-o-phenylenediamine. The position of labelling was confirmed by the appearance of two coupled resonances (JC-C=80.59 Hz) at 121.95 and 154.39 ppm in the assigned 13C-NMR spectrum. |
| Databáze: | OpenAIRE |
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