The synthesis of 1,2-benzothiazine-3-carboxamidylhydantoin derivatives and their antiinflammatory and analgesic activities

Autor:	Myoung-suk Park, Soon-Kyoung Kwon
Rok vydání:	1992
Předmět:	chemistry.chemical_classification Analgesic effect Aspirin Stereochemistry Organic Chemistry Xylene Analgesic Benzothiazine Pharmacology chemistry.chemical_compound chemistry Edema Drug Discovery medicine Molecular Medicine Foot edema medicine.symptom Alkyl medicine.drug
Zdroj:	Archives of Pharmacal Research. 15:251-255
ISSN:	1976-3786 0253-6269
DOI:	10.1007/bf02974065
Popis:	A number of 4-hydroxy-2H (or alkyl)-N-(3-aralkyl-2-thio-1-hydantoinyl)-1,2-benzothiazine-3-carboxamide 1,1-dioxides were synthesized through the reaction of 4-hydroxy-2H (or alkyl)-1,2-benzothiazine-3-carboxylic methyl ester 1,1-dioxide and 1-amino-2-thio-3-aralkyl-4-imidazolones in xylene. The compounds synthesized were screened for antiinflammatory effect on carrageeenin-induced edema in rat and for analgesic effect on acetic acid-induced Writhing syndrome in mice. Most compounds were inhibitors of carrageenin-induced rat foot edema and some showed significant antiinflammatory activity comparable to that of indomethacin and significant analgesic activity comparable to that of indomethacin and aspirin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7ca703e9a6d33eb9f654bcbbc148a7d6 https://doi.org/10.1007/bf02974065 Zobrazit plný text záznamu Full text from SpringerLink