Changes in bone density and metabolism in pregnancy
| Autor: | Renate Huch, Maurus Neff, Albert Huch, Ivrea Florio, Josef Wisser, Ursula von Mandach, Volker König |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Pregnancy biology Bone density medicine.diagnostic_test business.industry Obstetrics and Gynecology Parathyroid hormone General Medicine medicine.disease Bone remodeling Endocrinology medicine.anatomical_structure Calcitonin Internal medicine medicine Osteocalcin biology.protein Cortical bone Quantitative computed tomography business |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 84:349-354 |
| ISSN: | 0001-6349 |
| Popis: | Objective. The impact of pregnancy on maternal bone density remains unclear. As a prerequisite to investigate the pathophysiology of gestational bone metabolism, we sought to document the changes in bone metabolism biochemistry in conjunction with those in selective trabecular/cortical osteodensitometry between early and late pregnancy. Methods. A prospective, controlled study in a university hospital was conducted with 43 healthy women, 34 of them during uneventful pregnancy. The main outcome measures are trabecular and cortical bone density measured in the first and third trimesters using peripheral quantitative computed tomography in conjunction with a panel of bone metabolism parameters, including blood parathyroid hormone, calcitonin, osteocalcin, skeletal alkaline phosphatase, and the urinary desoxypyridinoline/creatinine ratio. Results. Cortical bone density was unaffected by pregnancy. Trabecular bone density changes showed wide interindividual variation, ranging from +1.3 to −20.7% per year, iden... |
| Databáze: | OpenAIRE |
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