Neutrophil-Lymphocyte Ratio as a Reliable Predictive Marker in Systemic Lupus Erythematosus
| Autor: | Enaam S. Abd El-Bar, Noha E. Esheba, Gehan M. Sheira, Hebatu Allah A. El-Habiby |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Autoimmune disease
Creatinine medicine.medical_specialty Predictive marker Systemic lupus erythematosus business.industry Lymphocyte fungi Urine medicine.disease Gastroenterology Disease course chemistry.chemical_compound medicine.anatomical_structure chemistry immune system diseases Internal medicine medicine skin and connective tissue diseases business Nephritis |
| Zdroj: | The Medical Journal of Cairo University. 86:919-925 |
| ISSN: | 2536-9806 |
| Popis: | Background: SLE is a complex autoimmune disease with heterogenous clinical manifestations and disease course, Nephritis is a major cause of morbidity and mortality in patients with lupus. Many clinical parameters and laboratory markers can be used to evaluate disease activity. NLR is positively associated with inflammatory disorders.Objectives: Is to evaluate the Neutrophil Lymphocytic ratio (NLR) as a reliable predictive and prognostic marker in systemic lupus erythematosus.Methods: The present study was carried out on 60 patients and 20 healthy individuals as controls. Patients were classified into: Group I: 40 SLE patients with active disease, which was sub divided into two subgroups: Group IA included thirty SLE patients with LN and Group IB included ten SLE patients with active disease without nephritis. Group II: 20 SLE patients with inactive disease. Group III: 20 apparently healthy vol-unteers as controls. CBC, serum creatinine, ESR, CRP, ANA, Anti-ds DNA, C3, C4, 24-hour protein in urine and urine analysis were done to all participants.Results: The NLR of SLE patients was significantly higher compared to that of the controls. Furthermore, SLE patients with nephritis had higher NLR levels than those without nephritis.Conclusion: NLR is a useful, simple and bed side inflam-matory marker for assessment of disease activity in patients with SLE. Also, NLR is a promising predictor of lupus ne-phritis. |
| Databáze: | OpenAIRE |
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