Synthesis of the hexapeptide 11–16 of the natural sequence of human calcitonin

Autor:	G. E. Rostovskaya, M. B. Smirnov, V. N. Karel'skii, E. P. Krysin, A. A. Antonov
Rok vydání:	1985
Předmět:	Natural sequence Homogeneous form Chemistry Plant Science General Chemistry New variant Optical rotation Combinatorial chemistry General Biochemistry Genetics and Molecular Biology Human calcitonin
Zdroj:	Chemistry of Natural Compounds. 21:520-523
ISSN:	1573-8388 0009-3130
DOI:	10.1007/bf00579150
Popis:	A new variant of the preparative synthesis of hexapeptide 11–16 of the natural sequence of human calcitonin is described. In several of the stages 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline was used successfully as the condensing agent. The final and intermediate compounds were obtained with good yields in chromatographically homogeneous form. Their purity was checked by TLC and measurements of angles of optical rotation. The final product was identified additionally by13C NMR. Several physicochemical characteristics of the compounds synthesized (angles of optical rotation, chromatographic mobilities) are given.
Databáze:	OpenAIRE
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