Vitrectomy for Prevention of Macular Holes
| Autor: | Gregg T. Kokame, Howard Schatz, Paul Sternberg, Cheryl Enger, Bruce R. Garretson, R. Joseph Olk, Ronald G. Michels, Thomas A. Rice, Patrick J. Murphy, Thomas M. Aaberg, Maureen G. Maguire, Rick D. Isernhagen, Jack O. Sipperley, David R. Williams, Brooks W. Mc Cuen, Howard D. Gilbert, Brian B. Berger, M. Gilbert Grand, Serge de Bustros, William J. Wood, Robert N. Johnson, H. Richard McDonald, Bert M. Glaser, Kirk H. Packo, William D. Freeman, Andrew P. Schachat |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures medicine.diagnostic_test business.industry medicine.medical_treatment Eye disease Vitrectomy Fundus (eye) Fluorescein angiography medicine.disease eye diseases Surgery law.invention Ophthalmology Randomized controlled trial law medicine sense organs medicine.symptom business Macular hole Retinopathy |
| Zdroj: | Ophthalmology. 101:1055-1060 |
| ISSN: | 0161-6420 |
| Popis: | Purpose: The purpose of this study is to assess the benefit of vitreous surgery in preventing full-thickness macular holes in patients with impending (stage 1) macular holes. Methods: A prospective randomized multicenter clinical trial was conducted on patients with full-thickness macular holes in their first eye (stage 3 or 4) and signs and symptoms of stage 1 macular holes in their fellow eye (study eye). The study eye was randomized to vitreous surgery or observation. Outcome was assessed by standardized measurement of visual acuity, detailed clinical examination, fundus photographs, and fluorescein angiography. Results: A full-thickness macular hole developed in 10 (37%) of 27 patients in the vitrectomy group compared with 14 (40%) of 35 patients randomized to observation ( P = 0.81). This difference of 3% has a 95% confidence interval of (-21%,27%). Conclusion: The study was terminated because of low recruitment. The authors were unable to prove (or disprove) the benefit of vitreous surgery in patients with stage 1 macular holes. The authors can state, however, that should a beneficial effect from vitrectomy exist, it would probably be minimal. Considering the cost and morbidity of vitreous surgery, a conservative approach for stage 1 macular hole might be appropriate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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