| Autor: |
Magdy A. Ragab, Abla A. Abou-Zeid, Rana Am Ahmed, Yehia F. El Garem |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Egyptian Journal of Dermatology and Venerology. 34:53 |
| ISSN: |
1110-6530 |
| DOI: |
10.4103/1110-6530.137313 |
| Popis: |
Background Acne vulgaris is a multifactorial disease, but recent studies have focused on the role of oxygen free radicals and antioxidant enzymes. Malondialdehyde (MDA) is the end product of lipid peroxidation and is a good marker of free radical-mediated damage and oxidative stress. Superoxide dismutase (SOD) represents the major cellular defense against superoxide anions. Objective The objective of this study was to study the role of oxidative stress in acne vulgaris and to detect a possible link with the different clinical severities. Patients and methods Fifty patients with acne vulgaris and 20 healthy controls were included in this study. The severity of the disease was assessed using the Global Acne Grading System. The levels of SOD in erythrocytes and MDA in plasma were measured using a spectrophotometer. Results Although higher SOD levels and mean values were present in patients, there was no statistically significant difference compared with the controls. MDA levels showed a significant difference between patients and controls ( P P P Conclusion Oxidative stress may play a role in the etiopathogenesis of acne and⁄or the progression of the disease. Coadministration of antioxidant drugs with various lines of treatment of acne might be helpful, especially for those with inflammatory lesions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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