| Autor: |
Konstantin Ershov, Nataliya Mazarchuk, Nikolai Kikhtenko, K.V. Bakhareva, Pavel Madonov, German Baikalov, Larisa Olejnik |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
2019 International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON). |
| DOI: |
10.1109/sibircon48586.2019.8958094 |
| Popis: |
Drugs based on interferon $\boldsymbol{\alpha}-2\mathbf{b}$ are highly effective in parenteral administration. When administered per os, their effectiveness is significantly less. Electron-beam immobilization of interferons $\boldsymbol{\alpha}-2\mathbf{b}$ allows to improve pharmacokinetic characteristics when taking per os. In the chamber of Ussing a high rate of absorption of immobilized interferon $\boldsymbol{\alpha}-2\mathbf{b} (\mathbf{imINF}\boldsymbol{\alpha}-2\mathbf{b})$ in the bowels up 5.46 ng/cm2 was estimated. In vivo experiments established that $\mathbf{imINF}\boldsymbol{\alpha}-2\mathbf{b}$ is actively absorbed from the lumen of the jejunum exclusively into the blood system. It was determined that $\mathbf{imINF}\boldsymbol{\alpha}-2\mathbf{b}$ concentration in $\boldsymbol{v}$ . mesenterica after 1h incubation 1.5-fold higher that native form of $\mathbf{INF}\boldsymbol{\alpha}-2\mathbf{b}$ . Unlike native $\mathbf{INF}\boldsymbol{\alpha}-2\mathbf{b}$ , the $\mathbf{imINF}\boldsymbol{\alpha}-2\mathbf{b}$ has better pharmacokinetic characteristics, so $\mathbf{imINF}\boldsymbol{\alpha}-2\mathbf{b}$ almost unchanged concentration passes through the liver, and passing through the kidneys, its concentration increases to a value of $7.18\pm 0.66$ ng/L. on the basis of the pharmacokinetic parameters of $\mathbf{imINF}\boldsymbol{\alpha}-2\mathbf{b}$ , such as the average retention time in the rat (MRT) — 9.98 hours; half–life (T 1/2 ) - 6.28 hours; maximum concentration (Cmax) −15.61 ng/mL; time to reach (Tmax) is 4 hours; average time of suction — 3.58 hours and clearance of 23.90 mL/HR, it can be argued that $\mathbf{imINF}\boldsymbol{\alpha}-2\mathbf{b}$ is the real prototype of the oral medicines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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