High prevalence of discordant human papillomavirus and p16 oropharyngeal squamous cell carcinomas in an African American cohort
| Autor: | Denise Gibbs, J. Robert Beck, Camille R. Ragin, Veda N. Giri, Shobha Parajuli, Anna Hull, Jeffrey C. Liu, Ashley Ellis, Jasvir S. Khurana, Patrick Iherjirka, Elizabeth Blackman |
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| Rok vydání: | 2015 |
| Předmět: |
Gynecology
Oncology medicine.medical_specialty Multivariate analysis business.industry Incidence (epidemiology) Cell virus diseases female genital diseases and pregnancy complications law.invention 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oropharyngeal Neoplasm Otorhinolaryngology law 030220 oncology & carcinogenesis Internal medicine Cohort medicine Immunohistochemistry Human papillomavirus 030223 otorhinolaryngology business Polymerase chain reaction |
| Zdroj: | Head & Neck. 38:E867-E872 |
| ISSN: | 1043-3074 |
| Popis: | Background Most studies on human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) have been performed on white Americans. Our study examined the incidence of HPV in an African American oropharyngeal SCC cohort and its survival. Methods African American patients with oropharyngeal SCC in a combined tumor registry were identified. HPV16 testing was performed by polymerase chain reaction (PCR) from DNA extracted from tumor blocks. The p16 staining was performed using standard immunohistochemistry. Results Forty-four patients were identified for analysis. Seventy-three percent of the tumors were HPV-positive. Only 39% of the patients who were HPV-positive were also p16-positive. Survival between all 3 tumor types, patients who tested HPV-positive/p16, HPV-positive/p16-positive, and HPV-negative/p16-negative was significantly different (p = .03). HPV/p16 status was significant on univariate and multivariate analysis. Conclusion HPV oropharyngeal SCC is strongly present in this African American cohort. Two thirds of the patients who were HPV-positive were p16-negative. Greater study is needed to explain the high p16 negativity among this HPV-positive oropharyngeal SCC African American cohort. © 2015 Wiley Periodicals, Inc. Head Neck, 2015 |
| Databáze: | OpenAIRE |
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