186Re-HEDP: A Potential Therapeutic Bone Agent

Autor:	Weininger J, Ketring Ar, Deutsch Ea
Rok vydání:	1984
Předmět:	Pathology medicine.medical_specialty Chromatography business.industry General Medicine High-performance liquid chromatography 186Re HEDP In vivo High pressure Labelling Medicine Radiology Nuclear Medicine and imaging business Animal species
Zdroj:	Nuklearmedizin. 23:81-82
ISSN:	2567-6407 0029-5566
DOI:	10.1055/s-0038-1624198
Popis:	SummaryA lyophilized kit preparation of HEDP for labelling with 186Re has been developed as a potential bone agent useful for both diagnosis and therapy. High pressure liquid chromatographic analysis showed that the 186Re-HEDP is a mixture of several components. Preliminary in vivo studies in several animal species showed that both the 186Re-HEDP mixture and the HPLC-purified main component are bone-seeking agents with slow blood and soft-tissue clearance rates. HPLC purification slightly improved the quality of the image. In mice and rats with trauma-induced osteogenetic activity in one leg, the bone uptake of the traumatized leg was 1.7-1.9 times higher than of the normal leg. The lesion-to-normal bone ratio was 4-5.4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c7081d65aba50ca3fda9128dd0e87bd https://doi.org/10.1055/s-0038-1624198 Zobrazit plný text záznamu