Ultrasound-enhanced nanotherapy of pancreatic cancer
| Autor: | N. Rapoport, K.-H. Nam, D. A. Christensen, A. M. Kennedy, J. E. Shea, C. L. Scaife, Kullervo Hynynen, Jacques Souquet |
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| Rok vydání: | 2010 |
| Předmět: |
Chemotherapy
Pathology medicine.medical_specialty endocrine system diseases Therapeutic ultrasound Combination therapy business.industry medicine.medical_treatment Ultrasound medicine.disease chemistry.chemical_compound Paclitaxel chemistry In vivo Pancreatic cancer medicine Cancer research Microbubbles business |
| Zdroj: | AIP Conference Proceedings. |
| ISSN: | 0094-243X |
| DOI: | 10.1063/1.3367120 |
| Popis: | The paper reports in vivo results of ultrasonic nanotherapy of orthotopically grown pancreatic cancer. Phase‐shift paclitaxel (PTX) loaded perfluoropentane (PFP) nanoemusions combined with tumor‐directed ultrasound have been used with a considerable success for tumor‐targeted chemotherapy of gemcitabin (GEM)‐refractory pancreatic cancer (PC). The GEM‐resistant pancreatic cancer proved sensitive to treatment by a micellar PTX formulation Genexol PM (GEN) andor nanodroplet PTX formulation ndGEN. Due to increased permeability of tumor blood vessels, drug‐loaded nanodroplets accumulated in the tumor via passive targeting, which was confirmed by ultrasound imaging. Nanodroplets converted into microbubbles in situ under the action of tumor‐directed 1‐MHz therapeutic ultrasound. The strongest therapeutic effect was observed for the combination therapy by PTX‐loaded nanodroplets, GEM and ultrasound (ndGEN+GEM+ultrasound). This combination therapy resulted in a spectacular tumor regression and in some cases comple... |
| Databáze: | OpenAIRE |
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