Autor:	N. V. Karsanov, G. V. Sukoyan, D. R. Tatulashvili, N. E. Guledani, L. T. Kuchava
Rok vydání:	2001
Předmět:	medicine.medical_specialty Contraction (grammar) business.industry General Medicine medicine.disease ALLERGIC MYOCARDITIS General Biochemistry Genetics and Molecular Biology Contractility Internal medicine Heart failure Myosin medicine Cardiology Energy deficit Myofibril business Actin
Zdroj:	Bulletin of Experimental Biology and Medicine. 132
ISSN:	0007-4888
DOI:	10.1023/a:1017933028308
Popis:	Experiments with hybrid myocardial fibers showed that abnormalities of actin (basic protein of fine sarcomer threads) are responsible for reduced contraction rate, decreased developed force, and low efficiency of cardiomyocyte contraction in chronic heart failure caused by dilatation and ischemic cardiomyopathies and infective allergic myocarditis. Wastefulness of the contractile process in cardiomyocyte under conditions of pronounced energy deficit play a key role in progression of chronic heart failure. Hence, actin hypothesis of reduced contractile activity of myocardial contractile protein system in acute heart failure transforms into the actomyosin concept in chronic heart failure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c6dd3f7fc07add8cc4ea7a2979ed0d8 https://doi.org/10.1023/a:1017933028308 Zobrazit plný text záznamu Full text from SpringerLink