The development and validation of a risk score for predicting microalbuminuria in type 2 diabetic patients
| Autor: | Jayanton Patumanond, Petch Rawdaree, Chamaiporn Tawichasri, Chulalux Komoltri, Sirima Mongkolsomlit |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Diabetes Mellitus. :227-233 |
| ISSN: | 2160-5858 2160-5831 |
| DOI: | 10.4236/jdm.2012.22036 |
| Popis: | Objective: To develop and validate a prognostic scoring scheme for the prediction of microalbuminuria in type 2 diabetic patients of Thai descent. Methods: The clinical information from type 2 diabetic patients who were treated at community hospitals was used to develop a prediction model (derivation set). The model evaluated at a tertiary hospital (validation set). A stepwise logistic regression model was used to identify the independent risk variables from the derivation set and a simple point scoring system was derived from the beta-coefficients. The risk scoring scheme was validated by the validation set. Results: The risk scoring scheme is based on six risk predictors: the duration of diabetes, age at the onset of diabetes, systolic blood pressure, low density lipoprotein levels, creatinine levels, and alcohol consumption. The total score ranged from 0 to 11.5. The likelihood of microalbuminuria in patients with low risk (scores ≤ 2) was 0.28, with moderate risk (scores 2.5 to 5.5) was 0.86, and high risk (scores ≥ 6) was 7.36. The area under the ROC curve of the derivation set and validation set were 0.768 (95% CI 0.73 - 0.81) and 0.758 (95% CI 0.70 - 0.80), respectively. Conclusion: Our scoring system is a simple and reasonably accurate method for predicting the future presence of microalbuminuria in type 2 diabetic patients. |
| Databáze: | OpenAIRE |
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