Brief Communication: Oncogenesis by Marek's Disease Herpesvirus in Chickens Lacking Expression of Endogenous (gs, Chick Helper Factor, Rous-Associated Virus-O) and Exogenous Avian RNA Tumor Viruses

Autor:	Lucy F. Lee, Richard L. Witter, W. Okazaki, R. E. Luginbuhl, B. R. Burmester, H. G. Purchase
Rok vydání:	1975
Předmět:	Cancer Research animal structures viruses RNA Endogeny Biology medicine.disease_cause Virology Virus Lesion Oncology Antigen Tumor Virus medicine medicine.symptom Carcinogenesis Gene
Zdroj:	JNCI: Journal of the National Cancer Institute. 55:215-218
ISSN:	1460-2105 0027-8874
Popis:	Chickens free of exogenous avian leukosis virus (ALV) infection, replicating endogenous ALV (Rous-associated virus-O), gs antigen, and chick helper factor were fully susceptible to induction of Marek's disease (MD) by ALV-free MD viruses. Dual infection with Rous-associated virus-2 and MD virus did not significantly alter the character of the MD lesions. Thus exogenous ALV infection was not requisite for MD virus-induced oncogenesis. Although participation of endogenous RNA tumor virus genes in MD lesion induction could not be excluded, expression of such genes in MD tumors as gs antigen was not established.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c6709db68b0b32e25000b65793ca631 https://doi.org/10.1093/jnci/55.1.215 Zobrazit plný text záznamu