Inhibition of human leukocyte elastase. 5. Inhibition by 6-alkyl substituted penem benzyl esters
| Autor: | H. Weston, Paul E. Finke, Alan L. Maycock, James B. Doherty, Mary Ellen Dahlgren |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Stereochemistry
medicine.drug_class Clinical Biochemistry Heteroatom Cephalosporin Pharmaceutical Science Biochemistry Human Leukocyte Elastase chemistry.chemical_compound mental disorders Drug Discovery polycyclic compounds medicine Molecular Biology Alkyl chemistry.chemical_classification biology Organic Chemistry Biological activity Enzyme chemistry Enzyme inhibitor Lactam biology.protein Molecular Medicine sense organs |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:2277-2282 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80939-2 |
| Popis: | Penem benzyl esters substituted at the 6-position with small alkyl groups and at the 3-position with a variety of carbon and heteroatom groups were prepared as inhibitors of human leukocyte elastase (HLE). The structure activity relations found for these positions are discussed in relation to know cephalosporin inhibitors and some important stereochemical implications are reported for inhibition of HLE by these β-lactam structures. |
| Databáze: | OpenAIRE |
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