Impact of Obesity on Outcomes of Elderly Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Myeloid Malignancies
| Autor: | William R. Drobyski, Mehdi Hamadani, Parameswaran Hari, Ensi Voshtina, Nirav N. Shah, Aniko Szabo, Tim S. Fenske, Anita D'Souza, Wael Saber |
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| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Blood. 128:4667-4667 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v128.22.4667.4667 |
| Popis: | Background Allogeneic hematopoietic cell transplantation (AHCT) is a high risk treatment option for patients (pts) with myeloid malignancies. Advanced age and obesity can impact outcomes after AHCT. Previous registry studies of all age groups found that obesity does not affect AHCT outcomes. However, obesity can hasten age-related decline in physical function and exacerbate comorbid conditions in older pts. In this study we evaluated outcomes of both non-obese and obese elderly pts undergoing AHCT for myeloid malignancies. Methods We performed a retrospective, single-center analysis of all pts age≥60 who underwent unrelated or related AHCT for myeloid malignancies (acute myeloid leukemia [AML], myelodysplastic syndrome [MDS], or myeloproliferative neoplasms [MPN]) between 2010 and 2015. Descriptive statistics were used to measure baseline characteristics. A hematopoietic cell transplant co-morbidity index (HCT-CI) score was calculated for all pts. Acute graft-versus-host disease (aGVHD) was defined as occurring in Results Of 86 pts that met inclusion criteria, 41 pts (48%) had a BMI≥30 and 45 pts (52%) had BMI5% blasts and 9 pts (20%) had >5% blasts in the BMI The median OS was 36 months (m) for BMI30 (p=0.10). One-year cumulative incidence of cGVHD was 56% (BMI≥30) vs 38% (BMI We performed an exploratory analysis of pts with BMI≥35 (N=15) compared to all other pts with BMI Conclusions In elderly pts (age>60) with myeloid malignancies undergoing AHCT, outcomes were not affected by either obesity or morbid obesity. Obesity was associated with increased re-hospitalization within 30 days of discharge after Tx. Morbidly obese pts had a trend towards a longer hospitalization stay and an increased rate of readmissions within 30 days of discharge from their Tx. In elderly pts, BMI should not preclude consideration of a curative AHCT. Figure 1 Figure 1. Figure 2 Figure 2. Table 1 Table 1. Disclosures Hamadani: Takeda: Research Funding. Shah:Oncosec: Equity Ownership; Exelixis: Equity Ownership; Geron: Equity Ownership. |
| Databáze: | OpenAIRE |
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