Effects of Wearing Bio-active Material Coated Fabric against γ-irradiation-induced Cellular Damage in Sprague-Dawley Rats
| Autor: | Hye Rim Kim, Jung Ae Kang, You Ree Nam, Hyo-Suk Park, Beom Su Jang, Sang Hyun Park, Sunhye Yoon, Gwang-Wung Yang, Young-Hwan Rho, Kyung-Chan Go |
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| Rok vydání: | 2016 |
| Předmět: |
Radiation
Antioxidant Materials science biology Health Toxicology and Mutagenesis medicine.medical_treatment Public Health Environmental and Occupational Health Aspartate transaminase Spleen Mitochondrion Pharmacology medicine.disease_cause Superoxide dismutase medicine.anatomical_structure Alanine transaminase In vivo medicine biology.protein Radiology Nuclear Medicine and imaging Oxidative stress |
| Zdroj: | Journal of Radiation Protection and Research. 41:206-210 |
| ISSN: | 2466-2461 2508-1888 |
| Popis: | Background: Ionizing radiation causes cellular damage and death through the direct damage and/or indirectly the production of ROS, which induces oxidative stress. This study was designed to evaluate the in vivo radioprotective effects of a bio-active material coated fabric (BMCF) against γ-irradiation-induced cellular damage in Sprague-Dawley (SD) rats. Materials and Methods: Healthy male SD rats wore bio-active material coated (concentrations in 10% and 30%) fabric for 7 days after 3 Gy of γ-irradiation. Radioprotective effects were evaluated by performing various biochemical assays including spleen and thymus index, WBC count, hepatic damage marker enzymes [aspartate transaminase (AST) and alanine transaminase (ALT)] in plasma, liver antioxidant enzymes, and mitochondrial activity in muscle. Results and Discussions: Exposure to γ-irradiation resulted in hepatocellular and immune systemic damage. Gamma-irradiation induced decreases in antioxidant enzymes. However, wearing the BMCF-30% decreased significantly AST and ALT activities in plasma. Furthermore, wearing the BMCF-30% increased SOD (superoxide dismutase) and mitochondrial activity. Conclusion: These results suggest that wearing BMCF offers effective radioprotection against γ-irradiation-induced cellular damage in SD rats. |
| Databáze: | OpenAIRE |
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