Discriminant analysis. 2. A new index for antitumor activity

Autor:	Gopalakrishnan Prakash, Jafargholi Amirmoazzami, Ernest M. Hodnett
Rok vydání:	1977
Předmět:	Antitumor activity Therapeutic index Index (economics) Chemistry Stereochemistry Lethal dose Biophysics Cell Biology Pharmacology Linear discriminant analysis Molecular Biology Atomic and Molecular Physics and Optics
Zdroj:	Journal of Biological Physics. 5:24-48
ISSN:	1573-0689 0092-0606
DOI:	10.1007/bf02310089
Popis:	The antitumor activities of 17 nitrogen analogs of 1, 4-benzoquinone, expressed in eight different ways, were subjected to discriminant analysis. Different methods of measuring the effectiveness of antitumor agents give different results. Methods based on dose levels such as the optimum dose or the lethal dose appear to be more useful in classifying compounds as antitumor agents than methods based on the maximum antitumor effect. A new index for antitumor activity involving the maximum antitumor effect, the optimum dose, and the therapeutic index, examined by discriminant analysis with substitutive parameters as discriminatory variables, can give valuable information for the design of new antitumor drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c42c3d4843c19b03481213bd6b02fb8 https://doi.org/10.1007/bf02310089 Zobrazit plný text záznamu Full text from SpringerLink