Vascular endothelial growth factor, tissue factor, coagulation and fibrinolysis markers in slow-flow vascular malformations: a prospective study of treatment with sirolimus

Autor: Annabel Maruani, Anne-Guillemette Moineau, Olivia Boccara, Juliette Mazereeuw-Hautier, Sophie Leducq, Didier Bessis, Laurent Guibaud, Pierre Vabres, Stephanie Mallet, Sebastien Barbarot, Christine Chiaverini, Catherine Droitcourt, Anne-Claire Bursztejn, Céline Lengelle, Jean-Baptiste Woillard, Denis Herbreteau, Anne Le Touze, Aurélien Binet, Baptiste Morel, Hélène Bourgoin, Valérie Gissot, Bruno Giraudeau, Yves Gruel, Elsa Tavernier, Jérôme Rollin
Rok vydání: 2022
Předmět:
Zdroj: British Journal of Dermatology. 188:152-154
ISSN: 1365-2133
0007-0963
DOI: 10.1093/bjd/ljac028
Popis: Slow-flow vascular malformations (VMs), especially those with venous components, can be complicated by localized intravascular coagulopathy (LIC), responsible for pain and impaired quality of life. Several studies have shown the effectiveness of mTOR inhibitors (especially sirolimus) on slow-flow VMs but its effect on coagulation has been poorly studied, especially in children. Our study shows that venous and combined VMs are associated with coagulation abnormalities and provides novel evidence that sirolimus improves coagulopathy in venous malformations. However we did not clearly evidence predictive biomarkers of response to sirolimus but this is the first study attempting to highlight predictive markers of response to sirolimus.
Databáze: OpenAIRE
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