Copper-catalysed N-arylation of 5-aminopyrazoles: a simple route to pyrazolo[3,4-b]indoles

Autor:	S. Peruncheralathan, Arpita Chatterjee, Chudamani Murmu
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Indole test Chemistry Organic Chemistry chemistry.chemical_element Biochemistry Medicinal chemistry Copper chemistry.chemical_compound Bromide Intramolecular force Halogen Physical and Theoretical Chemistry Alkyl
Zdroj:	Organic & Biomolecular Chemistry. 18:6571-6581
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d0ob00812e
Popis:	A copper-catalysed intramolecular N-arylation of 5-aminopyrazoles is demonstrated for the first time. Highly substituted pyrazolo[3,4-b]indoles are synthesized. In particular, the indole core is decorated with halogens and alkyl and methoxy groups. Furthermore, a selective N-arylation of unsymmetrical diaryl bromide containing pyrazoles is exemplified, resulting in valuable pyrazolo[1,5-a]benzimidazoles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c39a8f9857141084b865cccf5bf48b8 https://doi.org/10.1039/d0ob00812e Zobrazit plný text záznamu