Synthesis of ethyl cyanoethylphenylacetate

Autor:	F. B. Naidis, E. Z. Katsnel'son, I. A. Karpinskaya, A. S. Vitvitskaya
Rok vydání:	1981
Předmět:	Pharmacology organic chemicals Sodium Pharmacology toxicology Diethyl carbonate chemistry.chemical_element Hexamidine Benzyl cyanide Sodium salt chemistry.chemical_compound chemistry Bromide Drug Discovery medicine heterocyclic compounds Phenobarbital medicine.drug Nuclear chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 15:512-515
ISSN:	1573-9031 0091-150X
Popis:	Ethyl cyanoethylphenylacetate [ethyl 2-cyano-2-phenylbutanoate] (IV) -an important intermediate in the synthesis of the drugs hexamidine and phenobarbital -is obtained from benzyl cyanide (I) and diethyl carbonate (II) in the presence of sodium ethanolate followed by the ethylation of the sodium salt of ethyl cyanophenylacetate (III) so obtained with ethyl bromide in accordance with the following scheme [1-3]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c3775806971403631cc4e81f25922ab https://doi.org/10.1007/bf00758539 Zobrazit plný text záznamu Full text from SpringerLink