| Autor: |
Jun-Bo Chen, Hao-Peng Lv, Zheng Wang, Xiao-Peng Yang, Xing-Wang Wang, Bing-Bing Sun, Jun-Qi Zhang |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Organic Chemistry Frontiers. 7:796-809 |
| ISSN: |
2052-4129 |
| DOI: |
10.1039/d0qo00001a |
| Popis: |
A bifunctional organocatalyst catalyzed tandem annulation reaction between β,γ-unsaturated α-ketoesters with α-arylidene pyrazolinones was reported. The tandem Michael–aldol process allows access to optically active bi-spirocyclic pyrazolone and oxindole compounds in high yields with good to excellent enantioselectivity and diastereoselectivity. The resulting bi-spirocyclic compounds possess highly dense functionalized substituents, two all-carbon spiro quaternary stereocenters and one hemiketal stereogenic centers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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