Mixed Small Cell and Large Cell Neuroendocrine Carcinoma of the Endometrium' A Case Report and Literature Review

Autor:	Joshua Uyboco, Jeffrey So, Jose Moran, Maria Concepcion Cenizal, Mary Anne Cruz-Ignacio, Maximino Bello
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty business.industry medicine.medical_treatment Large cell Endometrial cancer Modified Radical Mastectomy medicine.disease Endometrium Radiation therapy Breast cancer medicine.anatomical_structure medicine business Lymph node Tamoxifen medicine.drug
Zdroj:	Philippine Journal of Pathology. 6:43-49
ISSN:	2507-8364 0118-3265
DOI:	10.21141/pjp.2021.05
Popis:	Neuroendocrine carcinoma (NEC) of the endometrium is a rare, aggressive subtype of endometrial cancer. We report a 61-year-old female with a history of breast cancer, s/p modified radical mastectomy, chemotherapy, radiotherapy and hormonal (tamoxifen) therapy, who presented with post-menopausal bleeding. Patient underwent TAH-BSO with lymph node dissection, and was diagnosed with a mixed small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC), confirmed by positive immunohistochemical staining for neuroendocrine markers. No other lesions were identified on PET-CT, making a primary endometrial NEC the most likely diagnosis. We review the clinical and pathologic characteristics of endometrial neuroendocrine carcinomas.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c2d3fc7cef42ff22658b8ca96223847 https://doi.org/10.21141/pjp.2021.05 Zobrazit plný text záznamu