Synthesis of 2-hydrazino- and 2-amino-1,3,4-thiadiazines containing polyhydric phenol residues in the 5 position

Autor:	I. Ya. Postovskii, A. P. Novikova, L. P. Sidorova, L. A. Chechulina
Rok vydání:	1976
Předmět:	chemistry.chemical_compound Thiocarbohydrazide Chemistry Organic Chemistry Hydrazine Organic chemistry Phenol Halide Ring (chemistry) Thiazole Medicinal chemistry
Zdroj:	Chemistry of Heterocyclic Compounds. 12:868-872
ISSN:	1573-8353 0009-3122
Popis:	2-Hydrazino-1,3,4-thiadiazines containing polyhydric phenol residues in the 5 position were obtained by reaction of 3,4-dihydroxy-, 2,5-dihydroxy-, and 2,3,4-trihydroxyphenacyl ω-halides with thiocarbohydrazide. 2-Amino-1,3,4-thiadiazines were obtained by reaction of 3,4-dihydroxy-and 2,5-dihydroxyphenacyl ω-halides with thiosemicarbazide in acidic and alcoholic media. In contrast to the dihydroxy derivatives, 2,3,4-trihydroxyphenacyl halide forms a 2-amino derivative only in strongly acidic media, whereas the isomeric thiazole compound with a hydrazine group in the 2 position of the thiazole ring is formed in alcoholic media.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7c245dfd0be497a917634468bb87e3d2 https://doi.org/10.1007/bf00510104 Zobrazit plný text záznamu Full text from SpringerLink