Sepsis attenuates the intensity of the neuromuscular blocking effect of d-tubocurarine and the antagonistic actions of neostigmine and edrophonium accompanying depression of muscle contractility of the diaphragm

Autor:	Yoshito Nakayama, Shinzoh Sumita, K. Satoh, Namiki A, Hiroshi Iwasaki, Eichi Narimatsu, Naoyuki Fujimura
Rok vydání:	1999
Předmět:	business.industry Neuromuscular transmission General Medicine Edrophonium Tubocurarine chloride Edrophonium Chloride Neostigmine Contractility Muscle tone Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia medicine business medicine.drug Phrenic nerve
Zdroj:	Acta Anaesthesiologica Scandinavica. 43:196-201
ISSN:	0001-5172
DOI:	10.1034/j.1399-6576.1999.430213.x
Popis:	Background: Prolonged effects of non-depolarizing muscle relaxants in septic patients have been reported, although the influence of sepsis on neuromuscular transmission has not yet been clarified satisfactorily. These studies were intended to elucidate the influence of sepsis on neuromuscular transmission and on the action of drugs being utilized for regulation of muscle tone (a neuromuscular blocker and anti-cholinesterase (anti-ChE) drugs). Methods: The effect of d-tubocurarine (dTc) on neuromuscular transmission and the antagonistic action of anti-ChE drugs (neostigmine and edrophonium) on dTc-induced twitch depression were estimated using sham control and septic rat nerve-hemidiaphragm preparations in vitro. Isometric twitch tension elicited by indirect (phrenic nerve) or direct (muscle) stimulation at 0.1 Hz was evaluated. Results: Sepsis induced by panperitonitis attenuated the twitch tension elicited by indirect or direct stimulation (P
Databáze:	OpenAIRE
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