| Autor: | H.G. Kress, Armin Sablotzki, R.G. Holzheimer, Karl Werdan, Ivar Friedrich, Rolf-Edgar Silber |
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| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Resuscitation business.industry Inflammation Critical Care and Intensive Care Medicine medicine.disease law.invention Cardiac surgery Proinflammatory cytokine Sepsis Systemic inflammatory response syndrome law Anesthesia Immunology medicine Cardiopulmonary bypass medicine.symptom business Multiple organ dysfunction syndrome |
| Zdroj: | Sepsis. 3:247-253 |
| ISSN: | 1385-0229 |
| Popis: | Cardiopulmonary bypass is associated with an injury that may cause pathophysiological changes in form of systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and mediator induced multi organ failure (MIMOV). Systemic endotoxinaemia, release of proinflammatory cytokines, and interactions between neutrophils and endothelium have been reported to correlate with a high incidence of organ dysfunctions, infections and sepsis following cardiac surgery. This review discusses the dysregulation of immune response as a major reason for the higher susceptibility to infections following cardiac surgery, various treatment strategies to reduce CPB-induced inflammation, and especially the prophylactic use of immunoglobulins in cardiac surgery. |
| Databáze: | OpenAIRE |
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