ASSOCIATION BETWEEN COMPUTED TOMOGRAPHIC CHARACTERISTICS AND FRACTURES FOLLOWING STEREOTACTIC RADIOSURGERY IN DOGS WITH APPENDICULAR OSTEOSARCOMA
| Autor: | Francis J. Bova, Kimberly A. Wirth, Atchar Sudhyadhom, Daniel J VanderHart, Rowan J. Milner, Kelvin Kow, James P. Farese, Qi An, Lyndsay Kubicek, Myron Chang, Nicholas J. Bacon |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Chemotherapy General Veterinary 040301 veterinary sciences business.industry medicine.medical_treatment Medical record Retrospective cohort study 04 agricultural and veterinary sciences medicine.disease Radiosurgery Computed tomographic 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Bone lesion 030220 oncology & carcinogenesis medicine Osteosarcoma Radiology Nuclear medicine business Cause of death |
| Zdroj: | Veterinary Radiology & Ultrasound. 57:321-330 |
| ISSN: | 1058-8183 |
| DOI: | 10.1111/vru.12351 |
| Popis: | The objective of this observational, descriptive, retrospective study was to report CT characteristics associated with fractures following stereotactic radiosurgery in canine patients with appendicular osteosarcoma. Medical records (1999 and 2012) of dogs that had a diagnosis of appendicular osteosarcoma and undergone stereotactic radiosurgery were reviewed. Dogs were included in the study if they had undergone stereotactic radiosurgery for an aggressive bone lesion with follow-up information regarding fracture status, toxicity, and date and cause of death. Computed tomography details, staging, chemotherapy, toxicity, fracture status and survival data were recorded. Overall median survival time (MST) and fracture rates of treated dogs were calculated. CT characteristics were evaluated for association with time to fracture. Forty-six dogs met inclusion criteria. The median overall survival time was 9.7 months (95% CI: 6.9-14.3 months). The fracture-free rates at 3, 6, and 9 months were 73%, 44%, and 38% (95% CI: 60-86%, 29-60%, and 22-54%), respectively. The region of bone affected was significantly associated with time to fracture. The median time to fracture was 4.2 months in dogs with subchondral bone involvement and 16.3 months in dogs without subchondral bone involvement (P-value = 0.027, log-rank test). Acute and late skin effects were present in 58% and 16% of patients, respectively. Findings demonstrated a need for improved patient selection for this procedure, which can be aided by CT-based prognostic factors to predict the likelihood of fracture. |
| Databáze: | OpenAIRE |
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