| Popis: |
Perfusion of the heart muscle is very heterogeneous, even in the healthy heart (Bassingthwaighte et al., 1989). The most important aspect is not the heterogeneity of perfusion or metabolism per se, but whether the blood delivers the oxygen necessary for metabolism. Whether perfusion is matched or not matched to aerobic metabolism is the question. Of course, a simple answer is that one must expect a good match in the healthy heart. Indeed, in healthy volunteers no myocardial lactate production is hidden under the net lactate extraction of the heart, not even during strenuous exercise (Kaijser and Berglund, 1992). However, it is predictable that mismatch will develop between perfusion and metabolism during ischemic disease and perhaps in other stressful situations such as cardiac hypertrophy. |
