Association of HLA antigens, ischaemic heart disease, and serum calcium levels: A preliminary report

Autor:	J. P. Pandey, H. Hugh Fudenberg, B. Roof, C. B. Loadholt
Rok vydání:	1978
Předmět:	Calcium metabolism Aging Geriatrics gerontology business.industry General Medicine Human leukocyte antigen Molecular medicine On cells Antigen Immunology Medicine Ischaemic heart disease Geriatrics and Gerontology business Serum Calcium Level
Zdroj:	AGE. 1:21-23
ISSN:	1574-4647 0161-9152
DOI:	10.1007/bf02432023
Popis:	HLA typing was performed for 17 antigens on cells from 239 unrelated Caucasians, 24 of whom had latent ischaemic heart disease as shown by abnormal EKG readings after exercise tests. The contingency χ2 test showed a significant increase in the frequency of HLA-B27 in the latter group. Further, the mean serum calcium level was found to be higher in people positive for B27 and lower in people positive for Bw40. These preliminary observations suggest that B27 may be involved in serum calcium metabolism and may be associated with predisposition or resistance to ischaemic heart disease, or resistance to death therefrom. Further studies will be required to differentiate between these possibilities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7bfba037dc6b025c4bbcdff9befa1f9c https://doi.org/10.1007/bf02432023 Zobrazit plný text záznamu Full text from SpringerLink