| Autor: |
Jan K. Korthals, Henryk M. Wiśniewski |
| Rok vydání: |
1975 |
| Předmět: |
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| Zdroj: |
Journal of the Neurological Sciences. 24:65-76 |
| ISSN: |
0022-510X |
| DOI: |
10.1016/0022-510x(75)90009-x |
| Popis: |
Following simultaneous ligation of the abdominal aorta and the femoral artery, extensive lesions were consistently produced in the nerves of the hind limb in the absence of gangrene in the ischemic leg. Total necrosis of all elements of nerve bundles was seen to involve most of the segment of tibial and peroneal nerves between the knee and the ankle. Distal portions of these nerves in the first days after vascular ligation appeared either morphologically normal or showed only minor changes. Later they underwent Wallerian degeneration. The morphologic features and dynamics of changes in the necrotic portion differed from the axonal degeneration seen in the more distal portions of the affected nerves. This model of peripheral nerve ischemia has two advantages in comparison to models used before, namely that: marked changes are produced in every cat, and there is no compression or stretching, or any manipulation of investigated nerves and thus there is no doubt that the changes are related to ischemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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