A Novel Glassy Carbon Electrode Modified with Multi-Walled Carbon Nanotubes for Potentiometric Xipamide Determination
| Autor: | Mahmoud A. Tantawy, Haitham A. El Fiky, Maha F. Abdel Ghany, Amr M. Badawey, N.V. Fares |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Renewable Energy Sustainability and the Environment Potentiometric titration Glassy carbon electrode Inorganic chemistry Carbon nanotube Condensed Matter Physics Surfaces Coatings and Films Electronic Optical and Magnetic Materials law.invention law Materials Chemistry Electrochemistry medicine Xipamide medicine.drug |
| Zdroj: | Journal of The Electrochemical Society. 168:056506 |
| ISSN: | 1945-7111 0013-4651 |
| DOI: | 10.1149/1945-7111/abfcdb |
| Popis: | Solid contact electrodes are widely used in analytical fields due to their outstanding performance over classical ones. However, they showed formation of a water layer affecting stability of those electrodes’ type. Herein, we develop a solid contact ion selective electrode to overcome this common drawback through application of multi-walled carbon nanotubes as a hydrophobic layer between the ion sensing membrane and a glassy carbon electrode. This fine modification improved stability of the electrode via preventing the formation of this water layer. The obtained potential was steady over 30 days with a drift of ∼0.8 mV h−1. The MWCNTs-modified electrode was used for determination of xipamide with a Nernstian slope of −56.01 over a linearity range of 1.0 × 10−5–1.0 × 10−2 mol l−1 and detection limit of 6.0 × 10−6 mol l−1. The proposed sensor was effectively applied for determination of the cited drug in its marketed pharmaceutical dosage form and spiked human plasma. |
| Databáze: | OpenAIRE |
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