| Autor: |
Osman Aydin, Berkay Küçük, Kemal Kismet, Ertugrul Ertas, Bülent Kiliçoğlu, Salih Tuncal, Zeynep Adiyaman, Pinar Celepli, Sema Hücümenoğlu, Yılmaz Ünal, Yusuf Murat Bağ, Mehmet Senes |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. 53:209-214 |
| ISSN: |
1304-6187 |
| DOI: |
10.20492/aeahtd.459184 |
| Popis: |
OBJECTIVE: It was aimed to demonstrate the efficacy of Calcium Dobesilate (Ca-Dob) in preventing postoperative intra-abdominal adhesion formation in an experimental cecal abrasion model. MATERIALS AND METHODS: Thirty female Wistar Albino rats were randomized into 3 groups. In the sham group, the cecum was removed from the abdomen and replaced without any further processing. In the control group, after cecal abrasion and peritoneal resection no processing was applied. In the Ca-Dob group, after cecal abrasion and peritoneal resection, 100 mg/kg/day Ca-Dob was administered. All rats were sacrificed on 21st day. The evaluation of adhesions was made through the degrees of bowel inflammation and fibrosis in tissue samples and the biochemical analysis of tissue and blood samples. RESULTS: Statistically, inflammation, microscopic adhesions and fibrosis scores were found to be significantly lower in the Ca-Dob administered rats compared to the control group (p < 0.05). Tissue MDA, FOP and TOS values were found to be significantly lower statistically compared to the control group (p = 0.001). Tissue total SH values were found to be statistically significantly higher (p < 0.05) in the sham group compared with the control group. Finally; serum MDA and serum TOS values in the Ca-Dob group, was statistically significantly lower (p < 0.05) compared to control group. CONCLUSION: Ca-Dob was found to be efficacious in preventing the formation of adhesions. In addition to the demonstrated anti-inflammatory effect histopathologically, the effect of antioxidant effect demonstrated biochemically was concluded to participate to the adhesion preventive efficacy of Ca-Dob. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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