Sulphonylurea drugs reduce hypoxic damage in the isolated perfused rat kidney

Autor:	Richard Engbersen, Paul Smits, H.B.P.M. Dijkman, Cees Kramers, Frans G. M. Russel, Alfons C. Wouterse, Miek M. Moons
Rok vydání:	2000
Předmět:	Pharmacology Kidney medicine.medical_specialty Chemistry Reabsorption Urinary system Hypoxia (medical) Glibenclamide Excretion medicine.anatomical_structure Tolbutamide Endocrinology Internal medicine medicine medicine.symptom Perfusion medicine.drug
Zdroj:	British Journal of Pharmacology. 130:1678-1684
ISSN:	0007-1188
DOI:	10.1038/sj.bjp.0703469
Popis:	Sulphonylurea drugs have been shown to protect against hypoxic damage in isolated proximal tubules of the kidney. In the present study we investigated whether these drugs can protect against hypoxic damage in a whole kidney preparation. Tolbutamide (200 microM) and glibenclamide (10 microM) were applied to the isolated perfused rat kidney prior to changing the gassing from oxygen to nitrogen for 30 min. Hypoxic perfusions resulted in an increased fractional excretion of glucose (FE % glucose 14.3+/-1.5 for hypoxic perfusions vs 4.9+/-1.6 for normoxic perfusions, mean +/- s.e. mean, P
Databáze:	OpenAIRE
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