Associations between HbA 1c and continuous glucose monitoring‐derived glycaemic variables

Autor: J. B. Welsh, David Price, T. C. Walker, P. Calhoun, S. Puhr, Irl B. Hirsch
Rok vydání: 2019
Předmět:
Zdroj: Diabetic Medicine. 36:1637-1642
ISSN: 1464-5491
0742-3071
Popis: Aims To identify clinically useful associations between HbA1c levels and various continuous glucose monitoring-derived metrics. Methods We retrospectively analysed end-of-study HbA1c levels and >2 weeks of continuous glucose monitoring data collected from 530 adults with Type 1 diabetes or insulin-requiring Type 2 diabetes during four randomized trials. Each trial lasted ≥24 weeks and provided central laboratory end-of-study HbA1c levels and continuous glucose monitoring data from the preceding 3 months. Participants were assigned to groups based on either HbA1c levels or continuous glucose monitoring-derived glucose values. Results HbA1c was strongly correlated with mean glucose value (r=0.80), time spent with glucose values in the 3.9-10.0 mmol/l range (time in range; r=-0.75) and percentage of glucose values >13.9 mmol/l (r=0.72), but was weakly correlated with the percentage of glucose values 13.9 mmol/l varied from 2.5% (0.6 h/day) to 27.8% (6.7 h/day) in the lowest and highest HbA1c groups, respectively. More than 90% of participants with either 13.9 mmol/l, mean glucose 80% had HbA1c levels ≤53 mmol/mol (≤7.0%). For participants with HbA1c ≥64 mmol/mol (≥8.0%), the median time in range was 44%, with 90% of participants having a time in range of Conclusions The associations shown in the present study suggest that continuous glucose monitoring-derived metrics may help guide diabetes therapy intensification efforts in an HbA1c -independent manner.
Databáze: OpenAIRE
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