Associations between HbA 1c and continuous glucose monitoring‐derived glycaemic variables
Autor: | J. B. Welsh, David Price, T. C. Walker, P. Calhoun, S. Puhr, Irl B. Hirsch |
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Rok vydání: | 2019 |
Předmět: |
Type 1 diabetes
Continuous glucose monitoring business.industry Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes medicine.disease Central laboratory 03 medical and health sciences Hba1c level 0302 clinical medicine Endocrinology Animal science Median time Diabetes mellitus Internal Medicine medicine 030212 general & internal medicine business |
Zdroj: | Diabetic Medicine. 36:1637-1642 |
ISSN: | 1464-5491 0742-3071 |
Popis: | Aims To identify clinically useful associations between HbA1c levels and various continuous glucose monitoring-derived metrics. Methods We retrospectively analysed end-of-study HbA1c levels and >2 weeks of continuous glucose monitoring data collected from 530 adults with Type 1 diabetes or insulin-requiring Type 2 diabetes during four randomized trials. Each trial lasted ≥24 weeks and provided central laboratory end-of-study HbA1c levels and continuous glucose monitoring data from the preceding 3 months. Participants were assigned to groups based on either HbA1c levels or continuous glucose monitoring-derived glucose values. Results HbA1c was strongly correlated with mean glucose value (r=0.80), time spent with glucose values in the 3.9-10.0 mmol/l range (time in range; r=-0.75) and percentage of glucose values >13.9 mmol/l (r=0.72), but was weakly correlated with the percentage of glucose values 13.9 mmol/l varied from 2.5% (0.6 h/day) to 27.8% (6.7 h/day) in the lowest and highest HbA1c groups, respectively. More than 90% of participants with either 13.9 mmol/l, mean glucose 80% had HbA1c levels ≤53 mmol/mol (≤7.0%). For participants with HbA1c ≥64 mmol/mol (≥8.0%), the median time in range was 44%, with 90% of participants having a time in range of Conclusions The associations shown in the present study suggest that continuous glucose monitoring-derived metrics may help guide diabetes therapy intensification efforts in an HbA1c -independent manner. |
Databáze: | OpenAIRE |
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