The value of lncRNAFENDRRandFOXF1as a prognostic factor for survival of lung adenocarcinoma
| Autor: | Sandra Rodriguez, Antonio Herrera-Merchan, Monica Saiz, Raul M. Torres, María Isabel Rodríguez, Isabel F. Coira, Marcos R. Estecio, Claudia Loidi, Marta Cuadros, Pedro Carmona-Sáez, Pedro P. Medina |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Prognostic factor medicine.medical_specialty Pathology Lung Cancer Biology medicine.disease Molecular cytogenetics 03 medical and health sciences 030104 developmental biology Real-time polymerase chain reaction medicine.anatomical_structure Internal medicine Chromosomal region medicine Adenocarcinoma Lung cancer |
| Zdroj: | Oncotarget. 11:1172-1185 |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.22154 |
| Popis: | // Antonio Herrera 1, 2, * , Marta Cuadros 1, 3, * , Maria Isabel Rodriguez 1, 2 , Sandra Rodriguez 4 , Raul Torres 4 , Marcos Estecio 5 , Isabel F. Coira 1, 2 , Claudia Loidi 6 , Monica Saiz 6 , Pedro Carmona-Saez 1 and Pedro P. Medina 1, 2 1 Centre for Genomics and Oncological Research, PTS Granada, Centro Pfizer - Universidad de Granada - Junta de Andalucia de Genomica e Investigacion Oncologica (GENYO), Granada, Spain 2 Department of Biochemistry and Molecular Biology I, University of Granada, Granada, Spain 3 Department of Biochemistry and Molecular Biology III e Immunology, University of Granada, Granada, Spain 4 Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre-CNIO, Madrid, Spain 5 Department of Epigenetics and Molecular Carcinogenesis, UT MD Anderson Cancer Center, Houston, TX, USA 6 Pathological Anatomy, Universitary Hospital Cruces, University of Pais Vasco, Spain * These authors have contributed equally to this work Correspondence to: Pedro P. Medina, email: pedromedina@ugr.es Keywords: lncRNA; FENDRR; FOXF1; lung cancer; methylation Received: June 09, 2017 Accepted: October 02, 2017 Published: October 27, 2017 ABSTRACT It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1 ) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p |
| Databáze: | OpenAIRE |
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