Serum sclerostin levels in rheumatoid arthritis
| Autor: | Amr Mahmoud Abdelsamad, Amir Helmy, Naglaa Farouk, Soha Eldessouki Ibrahim |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
Autoimmune disease medicine.medical_specialty medicine.diagnostic_test business.industry Wnt signaling pathway Magnetic resonance imaging Wrist medicine.disease Gastroenterology chemistry.chemical_compound medicine.anatomical_structure Rheumatology chemistry Internal medicine Rheumatoid arthritis Synovitis Immunology medicine Sclerostin In patient business |
| Zdroj: | Indian Journal of Rheumatology. 10:117-120 |
| ISSN: | 0973-3698 |
| DOI: | 10.1016/j.injr.2015.05.002 |
| Popis: | Background Rheumatoid arthritis (RA) is an autoimmune disease that may lead to joint destruction and disability. Wingless (Wnt) pathway is involved in bone formation and has been found to contribute to bone loss in RA. Sclerostin is a key molecule in Wnt pathway. Objective To study the serum levels of sclerostin in rheumatoid arthritis patients and to study its association with radiological changes. Methods Forty-five patients with RA and 45 age and gender matched healthy controls were enrolled. Serum sclerostin was measured by ELISA. Modified version of Larsen score was used to assess joint damage in radiographs and Magnetic resonance imaging (MRI) of wrist and hand was assessed for synovitis and bone erosion. Results Serum sclerostin levels were higher in patients with RA as compared to controls (p Conclusion Increased serum levels of sclerostin may play a role in joint damage and bone erosion in RA. |
| Databáze: | OpenAIRE |
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