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The effects of zolpidem, triazolam, and diazepam on performance in an eight-arm radial maze task were studied in the rat. Errors were based on arm entries as well as nose pokes in a food trough and were summed across the number of correct choices remaining. As measures of motivation, number of pellets retrieved, number of arm entries, total time in maze, and time from arm entry to nose poke were recorded. Triazolam and diazepam resulted in a greater performance decrement than did zolpidem. Furthermore, triazolam and diazepam appeared to have a sedative effect on the animals that did not affect the motor control needed to complete the task. The present results suggest that the BZ-1-specific hypnotic, zolpidem, did not produce sedative or performance effects as profound as those produced by the nonselective benzodiazepines, triazolam and diazepam. |
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