The Impact of NOTCH1 in the Prognosis of Chronic Lymphocytic Leukemia (CLL)
| Autor: | Julio C. Chavez, Jamie K. Teer, Jennifer Rock-Klotz, Javier Pinilla-Ibarz, Ateefa Chaudhury |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research Chemotherapy Mutation medicine.medical_specialty business.industry medicine.medical_treatment Chronic lymphocytic leukemia Cancer Aggressive phenotype Hematology Disease medicine.disease medicine.disease_cause hemic and lymphatic diseases Internal medicine embryonic structures medicine Prognostic biomarker business Exome sequencing |
| Zdroj: | Clinical Lymphoma Myeloma and Leukemia. 15:S205-S206 |
| ISSN: | 2152-2650 |
| DOI: | 10.1016/j.clml.2015.04.067 |
| Popis: | Background: NOTCH1 mutations have been identified as a poor prognostic biomarker associated with a more aggressive phenotype, increased rate of Richter’s transformation, and decreased response to FCR chemotherapy in high-risk patients with Chronic Lymphocytic Leukemia (CLL). This study seeks to characterize the role of NOTCH1 mutation with overall survival (OS) and progression of disease resulting in treatment of CLL patients at H. Lee Moffitt Cancer Center who underwent Targeted Exome Sequencing (TES). |
| Databáze: | OpenAIRE |
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