Role of Neuromodulators in Aspirin Induced Gastric Ulceration

Autor:	D. N. Srivastava, Y. P. Sahni
Rok vydání:	1992
Předmět:	Aspirin General Veterinary business.industry Pharmacology Cyproheptadine digestive system diseases Promethazine Ranitidine chemistry.chemical_compound chemistry Anesthesia Medicine Animal Science and Zoology business Histamine medicine.drug
Zdroj:	Journal of Applied Animal Research. 2:27-31
ISSN:	0974-1844 0971-2119
DOI:	10.1080/09712119.1992.9705928
Popis:	The role of neuromodulators, viz. histamine and 5- hydroxytryptamine in aspirin (200 mg/kg, oral) induced gastric ulcers was studied by pretreating the rats with their specific antagonists; promethazine (10 mg/kg), ranitidine (20 mg/kg) and cyproheptadine (5 and 10 mg/kg), intraperitoneally, one hour prior to aspirin administration. Promethazine and ranitidine failed to produce any effect on gastric ulcers caused by aspirin. Cyproheptadine, however, produced dose related protective effect on aspirin induced gastric ulcers which suggested the involvement of 5-hydroxytryptamine in gastric ulcers induced by aspirin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7ba05a6648a5d32183addef83e0f3bf3 https://doi.org/10.1080/09712119.1992.9705928 Zobrazit plný text záznamu