Mechanism of the effect of levorin on transport of amino acids inCandida albicans

Autor:	A. S. Obukhovskaya, I. M. Tereshin, E. B. Lishnevskaya
Rok vydání:	1979
Předmět:	chemistry.chemical_classification Alanine Leucine transport Stereochemistry Phenylalanine General Medicine Polyene Applied Microbiology and Biotechnology Microbiology Amino acid chemistry.chemical_compound chemistry Biochemistry Glycine Proline Leucine
Zdroj:	Current Microbiology. 2:219-222
ISSN:	1432-0991 0343-8651
Popis:	By use of incubation media of various ionic compositions and pH's, it was possible to reveal that inhibition of the transport of neutral amino acids having long hydrophobic chains (leucine, phenylalanine) inCandida albicans by the polyene antibiotic levorin was mainly due to redistribution—caused by the antibiotic—of monovalent cations in the cells and protoplasts of the yeast. In an acidic medium, levorin was also found to induce a decrease of proton release from the cells, accompanied by some inhibition of leucine transport. Transport of neutral amino acids having short hydrophobic chains (alanine, glycine, proline) was inhibited by this polyene antibiotic, irrespective of the ionic composition or pH of the medium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b9dbed068cd9eced18d93d162e4c848 https://doi.org/10.1007/bf02601716 Zobrazit plný text záznamu Full text from SpringerLink