Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate
| Autor: | Andrew John Intelli, Mohan Pal, Manikandan Selvaraju, Ryan A Altman |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Synthesis. |
| ISSN: | 1437-210X 0039-7881 |
| Popis: | A Pd-catalyzed decarboxylative dearomatization reaction of of a heterocyclic substrate enables access to an uncommon reaction intermediate, that rearomatizes in the presence of amine bases in a net C–H functionalization sequence. The dearomatized benzo[b]thiophene intermediate bears an exocyclic alkene that can be functionalized through cycloaddition and halogenation reactions to deliver complex heterocyclic products. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|