Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate
Autor: | Andrew John Intelli, Mohan Pal, Manikandan Selvaraju, Ryan A Altman |
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Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Synthesis. |
ISSN: | 1437-210X 0039-7881 |
Popis: | A Pd-catalyzed decarboxylative dearomatization reaction of of a heterocyclic substrate enables access to an uncommon reaction intermediate, that rearomatizes in the presence of amine bases in a net C–H functionalization sequence. The dearomatized benzo[b]thiophene intermediate bears an exocyclic alkene that can be functionalized through cycloaddition and halogenation reactions to deliver complex heterocyclic products. |
Databáze: | OpenAIRE |
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