Role of calcitriol in modulating of placental dysfunction in pregnant women with chronic kidney disease
| Autor: | N. V. Didenkul, Z. V. Chumak, L. V. Mnich, G. S. Manasova, N. V. Kuzmin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pregnancy
medicine.medical_specialty Kidney 030219 obstetrics & reproductive medicine Calcitriol business.industry General Medicine Bacteriuria Urine medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Placental dysfunction Internal medicine medicine Vitamin D and neurology 030212 general & internal medicine business medicine.drug Kidney disease |
| Zdroj: | Proceedings of the National Academy of Sciences of Belarus, Medical series. 17:493-499 |
| ISSN: | 2524-2350 1814-6023 |
| DOI: | 10.29235/1814-6023-2020-17-4-493-499 |
| Popis: | The pleiotropic effects of vitamin D (VD), whose active form is synthesized in the kidneys, play a certain role both in forming and functioning the feto-placental system, including various pregnancy complications. The aim of the study was to evaluate the vitamin D status in pregnant women with placental dysfunction (PD) and chronic inflammatory kidney disease (CIKD). During 24–34 pregnancy weeks, 56 pregnant women with PD were examined (main group ‒ I); 24 patients (42.85 %) had chronic pyelonephritis (group IA). The control group (group II) had 31 conditionally healthy pregnant women. The total VD level in the blood was determined by ELISA; in addition to the general clinical standard examination, the urine also underwent bacteriological examination. The VD mean level in pregnant women with PD and CIKD was significantly lower than that in the control group (31.08 ± 7.2 and 45.42 ± 9.67 ng/ml (p 2 = 66.67; p |
| Databáze: | OpenAIRE |
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