Purpura fulminans et thrombose veineuse compatible avec une thrombophilie constitutionnelle chez un nourrisson
| Autor: | K. Mortaji, K. Khadir, F Lasry, H. Benchikhi, M. Itri, F. Fadil, Sellama Nadifi, Fz Elfatoiki, N. Sarbati |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Disseminated intravascular coagulation
medicine.medical_specialty business.industry Antithrombin Follow up studies Werlhof's disease medicine.disease Factor ii Thrombophilia Gastroenterology Venous thrombosis Internal medicine Pediatrics Perinatology and Child Health medicine business medicine.drug Heterozygous mutation |
| Zdroj: | Archives de Pédiatrie. 20:499-502 |
| ISSN: | 0929-693X |
| DOI: | 10.1016/j.arcped.2013.02.077 |
| Popis: | The association of idiopathic purpura fulminans (PF) and venous thrombosis (VT) seldom reveals constitutional thrombophilia in an infant. We report a case of PF in an 18-month-old infant. Laboratory tests showed disseminated intravascular coagulation (DIVC) with normal rates of C and S proteins and antithrombin. The echo-Doppler examination conveyed venous thrombosis of the lower limbs, while the genetic study showed heterozygous mutation of Factor II (G 20210A). Precocious and multidisciplinary management included frozen fresh plasma supplementation and necrosectomy with skin grafts. The diagnosis and therapeutic problems posed by PF combined with deep venous thrombosis are discussed. |
| Databáze: | OpenAIRE |
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