[3,3]-Sigmatropic Rearrangement Routes to β-Fluoro- and β,β-Difluoro-carbonyl Derivatives

Autor:	S. T. Patel, Robin Wilkes, Jonathan M. Percy
Rok vydání:	1995
Předmět:	Chemistry Yield (chemistry) Organic Chemistry Drug Discovery Carbonyl derivatives Sigmatropic reaction Biochemistry Medicinal chemistry
Zdroj:	Tetrahedron. 51:11327-11336
ISSN:	0040-4020
DOI:	10.1016/0040-4020(95)00694-4
Popis:	Difluoroallylic alcohols prepared in two steps from trifluoroethanol underwent a range of Claisen and related [3,3]-rearrangements in moderate to good yield. In one case, the rearrangement product underwent rapid dehydrofluorination to afford an interesting fluorodienal Monofluoroallylic alcohols rearranged more slowly but resisted dehydrofluorination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b6c5fc9c6aff8360ece8fe79be2ffd1 https://doi.org/10.1016/0040-4020(95)00694-4 Zobrazit plný text záznamu Full Text from ScienceDirect