Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviours during the breeding season

Autor: Toshiya Nishimura, Tomoya Nakayama, Takumi Senga, Ai Shinomiya, Takashi Yoshimura, Tsuyoshi Shimmura, Yusuke Takehana, Mana Nakatsukasa, Kiyoshi Naruse, Yuko Furukawa, Kousuke Okimura, Minoru Tanaka, Kataaki Okubo, Takayuki Shimo, Yasuhiro Kamei
Rok vydání: 2019
Předmět:
Zdroj: Nature Ecology & Evolution. 3:845-852
ISSN: 2397-334X
DOI: 10.1038/s41559-019-0866-6
Popis: To cope with seasonal environmental changes, animals adapt their physiology and behaviour in response to photoperiod. However, the molecular mechanisms underlying these adaptive changes are not completely understood. Here, using genome-wide expression analysis, we show that an uncharacterized long noncoding RNA (lncRNA), LDAIR, is strongly regulated by photoperiod in Japanese medaka fish (Oryzias latipes). Numerous transcripts and signalling pathways are activated during the transition from short- to long-day conditions; however, LDAIR is one of the first genes to be induced and its expression shows a robust daily rhythm under long-day conditions. Transcriptome analysis of LDAIR knockout fish reveals that the LDAIR locus regulates a gene neighbourhood, including corticotropin releasing hormone receptor 2, which is involved in the stress response. Behavioural analysis of LDAIR knockout fish demonstrates that LDAIR affects self-protective behaviours under long-day conditions. Therefore, we propose that photoperiodic regulation of corticotropin releasing hormone receptor 2 by LDAIR modulates adaptive behaviours to seasonal environmental changes.
Databáze: OpenAIRE
Externí odkaz: